Bluestone Trials

Mouthwash study

Are you in good general and oral health and would like to participate in a mouthwash study?
Status: Completed.

If you are at least 18 years old and in good general and oral health, you might be eligible to participate in a research study at the NYU Bluestone Center where we regularly test the effectiveness of new products or devices such as toothbrushes, toothpastes and mouthwashes in relation to oral health, dental plaque formation, salivary function and sensitivity.

The oral health studies consist of one to several visits and you will be required to have a full oral examination. To qualify you should be in a good oral and general health and may have a dental cleaning performed.  You must be willing to comply with study procedures and required study participation visits. Participants will be compensated for time and travel expenses, if they qualify. 

Study background:

Currently we are running a study where its main purpose is to compare the impact of an alcohol-based mouthrinse to a non-alcohol based mouthrinse on salivary function and perceived dryness following extended daily use over a 3-month period. Other objectives of this study include comparing perceived dryness measures and other factors related to “mouthfeel” following extended daily use of an alcohol-based mouthrinse and a non-alcohol based mouthrinse.


* Mouthrinses are used for a variety of reasons: to freshen breath, to help prevent or control tooth decay, to reduce plaque (a thin film of bacteria that forms on teeth), to prevent or reduce gingivitis (an early stage of gum disease), to reduce the speed that tartar (hardened plaque) forms on the teeth, or to produce a combination of these effects. Most mouthrinses are available without a prescription.


Basic ingredients commonly found in mouthrinse include water, alcohol, cleansing agents, flavoring ingredients and coloring agents. Active ingredients vary depending on the type of mouthrinse, but they can be placed into four general groups: (1) Antimicrobial agents act directly on oral bacteria to help reduce plaque, decrease the severity of gingivitis and control bad breath; (2) Fluoride helps reduce tiny lesions (tooth decay) on tooth enamel and make teeth more resistant to decay; (3) Astringent salts can serve as temporary deodorizers that mask bad breath; and (4) Odor neutralizers act by chemically inactivating odor-causing compounds.