Bluestone Trials

Do you have Gum Disease?

The purpose of this study is to find out which germs make gum disease worse.
Status: Completed.

PLEASE NOTE: We can no longer accept new participants for this study. 

If you are at least 25 years of age, have at least 20 natural teeth, have gum disease, have not used tobacco products for at least a year, you may qualify to participate in a research study at the NYU Bluestone Center for Clinical Research.

This study consists of approximately 14 visits to our study site, over a 21 months period. Each visit will last approximately 1 to 3 hours.  

There will be no cost for treatment for eligible participants.

To determine if you qualify for this study, please call 212-998-9310 or email to find out more information.

Study Details:
Periodontal (gum) diseases, including gingivitis and periodontitis, are serious infections that, left untreated, can lead to tooth loss. The word periodontal literally means "around the tooth" and when patients are affected by this condition a chronic bacterial infection affects the gums and bone supporting the teeth. Periodontal disease can affect one tooth or many teeth. It begins when the bacteria in plaque (the sticky, colorless film that constantly forms on your teeth) causes the gums to become inflamed. Signs and symptoms of the disease may include red, swollen or tender gums or other pain in your mouth, bleeding while brushing, flossing, or eating hard food, gums that are receding or pulling away from the teeth, causing the teeth to look longer than before, loose or separating teeth, pus between your gums and teeth sores in your mouth, persistent bad breath. (for more information, please visit: American Academy of Periodontology; (
The purpose of this research study is to find better tests to determine which people with gum disease will have worsening of their gum disease. The study will require between 9 and 14 visits. During the study, we will take x-rays, draw blood samples, collect saliva and plaque, and take fluid from the spaces between your gums and teeth. We will also examine your teeth and gums. Your gum condition will be very carefully monitored during the entire length of the study.

The study will have three parts: 1) a screening visit, 2) visits where we monitor your gum condition and 3) dental treatment and additional monitoring of your gum condition. For the first 12 months of the study, you will be seen every two months and we will take measurements of your gums and collect blood, plaque, saliva, and gum fluid. During these 12 months you will be asked to not seek professional dental cleaning or gum disease therapy outside of the study. You will be closely monitored and treated if there is gum disease progression. At the end of the 12 months you will receive free dental care. If you have gum disease we will monitor and provide treatment of your gum condition for another six months. At the beginning of the study you will be instructed on how to brush and floss your teeth, and the risks of gum disease.